<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:Wingdings;
panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
p.MsoListParagraph, li.MsoListParagraph, div.MsoListParagraph
{mso-style-name:"List Paragraph\,GFX";
mso-style-priority:34;
mso-style-link:"List Paragraph Char\,GFX Char";
margin-top:0cm;
margin-right:0cm;
margin-bottom:8.0pt;
margin-left:36.0pt;
mso-add-space:auto;
line-height:105%;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
p.MsoListParagraphCxSpFirst, li.MsoListParagraphCxSpFirst, div.MsoListParagraphCxSpFirst
{mso-style-name:"List Paragraph\,GFXCxSpFirst";
mso-style-priority:34;
mso-style-link:"List Paragraph Char\,GFX Char";
mso-style-type:export-only;
margin-top:0cm;
margin-right:0cm;
margin-bottom:0cm;
margin-left:36.0pt;
mso-add-space:auto;
line-height:105%;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
p.MsoListParagraphCxSpMiddle, li.MsoListParagraphCxSpMiddle, div.MsoListParagraphCxSpMiddle
{mso-style-name:"List Paragraph\,GFXCxSpMiddle";
mso-style-priority:34;
mso-style-link:"List Paragraph Char\,GFX Char";
mso-style-type:export-only;
margin-top:0cm;
margin-right:0cm;
margin-bottom:0cm;
margin-left:36.0pt;
mso-add-space:auto;
line-height:105%;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
p.MsoListParagraphCxSpLast, li.MsoListParagraphCxSpLast, div.MsoListParagraphCxSpLast
{mso-style-name:"List Paragraph\,GFXCxSpLast";
mso-style-priority:34;
mso-style-link:"List Paragraph Char\,GFX Char";
mso-style-type:export-only;
margin-top:0cm;
margin-right:0cm;
margin-bottom:8.0pt;
margin-left:36.0pt;
mso-add-space:auto;
line-height:105%;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
span.ListParagraphChar
{mso-style-name:"List Paragraph Char\,GFX Char";
mso-style-priority:34;
mso-style-link:"List Paragraph\,GFX";}
span.highwire-cite-metadata-doi
{mso-style-name:highwire-cite-metadata-doi;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
{page:WordSection1;}
/* List Definitions */
@list l0
{mso-list-id:535852822;
mso-list-type:hybrid;
mso-list-template-ids:-1441214562 134807553 134807555 134807557 134807553 134807555 134807557 134807553 134807555 134807557;}
@list l0:level1
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:Symbol;}
@list l0:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:"Courier New";}
@list l0:level3
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:Wingdings;}
@list l0:level4
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:Symbol;}
@list l0:level5
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:"Courier New";}
@list l0:level6
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:Wingdings;}
@list l0:level7
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:Symbol;}
@list l0:level8
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:"Courier New";}
@list l0:level9
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:none;
mso-level-number-position:left;
text-indent:-18.0pt;
font-family:Wingdings;}
@list l1
{mso-list-id:1137651512;
mso-list-template-ids:-2091456274;}
@list l1:level1
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:36.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level2
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:72.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level3
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:108.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level4
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:144.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level5
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:180.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level6
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:216.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level7
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:252.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level8
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:288.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l1:level9
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:324.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
ol
{margin-bottom:0cm;}
ul
{margin-bottom:0cm;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-GB" link="#0563C1" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal"><span style="font-size:12.0pt">***apologies if you receive this more than once***<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt">The Turing is offering an exciting opportunity for early career researchers and post-docs to become Data Study Group PIs for projects relating to Dementia Research. (Experience in the field of dementia is
not a requirement, the useful data science skills listed below each project is really what we are looking for.)<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt">The Data Study Group (DSG) PIs will scope and shape a challenge for the Turing’s
<a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.turing.ac.uk%2Fcollaborate-turing%2Fdata-study-groups&data=04%7C01%7CTuring-Southampton%40ecs.soton.ac.uk%7C49e717b1367947ef2c0a08d92a80ba5b%7C4a5378f929f44d3ebe89669d03ada9d8%7C0%7C0%7C637587554624948318%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=u9Q%2BgCvAETwkfdxxOjIC6WrqilQy6Uunx8vywxW85yg%3D&reserved=0" originalsrc="https://www.turing.ac.uk/collaborate-turing/data-study-groups" shash="UHRMPhU38KF6B9jMwx8XWSfCdhNWqDAL6jcTodNgrrbOrnwoede5do1r499ngDX24akcTTI2REpXEcMx1dTw1K0sv+vqJPPv69TDr505nAvb9G+52S7lbm9qT2EayKFLHxC7FchglSZ+JmVKg55cK8bqkdTlY4O6fW54LrO0d0Q=">
DSG</a> with potential for continued and expanded follow up work after the event. The Turing will administrate contracts, IT and researchers, and fully support the DSG PI, while their sole focus will be on the scientific questions to be investigated. For further
information on the DSG PI role please visit <a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.turing.ac.uk%2Fcollaborate-turing%2Fdata-study-groups%2Fget-involved-pi&data=04%7C01%7CTuring-Southampton%40ecs.soton.ac.uk%7C49e717b1367947ef2c0a08d92a80ba5b%7C4a5378f929f44d3ebe89669d03ada9d8%7C0%7C0%7C637587554624958274%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=5FdrffalrTL9abnFEgpAp4ojEFCXcLBArsu%2BUI8emEA%3D&reserved=0" originalsrc="https://www.turing.ac.uk/collaborate-turing/data-study-groups/get-involved-pi" shash="ZG6z+N/Oec4ES6jykaYeYorw+NMKa3ciHR7p1mpHrnfrQ/8tRQ3tFG7arr70BmYr16Sutuz2v+2pji1I/dUHAVHtMT6YTWQXdD/CNMoYKPfdVVq60XlAssuTNc5FBPVDoC3IBm7nk2+KH3TfTeaO5DhcoYTKpYNObBAAqWnbDh8=">
https://www.turing.ac.uk/collaborate-turing/data-study-groups/get-involved-pi</a><span class="MsoHyperlink">.</span><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt">This is an exceptional opportunity to
<o:p></o:p></span></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoListParagraphCxSpFirst" style="margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:normal;mso-list:l0 level1 lfo3">
<span style="font-size:12.0pt">Build industry connections whilst working alongside challenge owners.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:normal;mso-list:l0 level1 lfo3">
<span style="font-size:12.0pt">Generate projects from loosely defined questions<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:normal;mso-list:l0 level1 lfo3">
<span style="font-size:12.0pt">Work at the cross section of industry and academia<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:normal;mso-list:l0 level1 lfo3">
<span style="font-size:12.0pt">Be involved in multidisciplinary teams<o:p></o:p></span></li><li class="MsoListParagraphCxSpLast" style="margin-bottom:0cm;margin-left:0cm;mso-add-space:auto;line-height:normal;mso-list:l0 level1 lfo3">
<span style="font-size:12.0pt">Get involved with The Turing Institute<o:p></o:p></span></li></ul>
<p class="MsoNormal"><b><u><span style="font-size:12.0pt"><o:p><span style="text-decoration:none"> </span></o:p></span></u></b></p>
<p class="MsoNormal"><span style="font-size:12.0pt">The projects have come through the UK Dementia Research Institute (UK DRI) & the details are:<o:p></o:p></span></p>
<p><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Challenge:
</span></strong><b><span style="font-size:12.0pt">Predicting amyloid plaque morphology from gene expression data in Alzheimer’s disease<o:p></o:p></span></b></p>
<p><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Essential skills:
</span></strong><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;font-weight:normal">Experience of spatial & predictive modelling, Machine Learning, feature selection, image analysis
</span></strong><strong><span style="font-family:"Calibri",sans-serif"><o:p></o:p></span></strong></p>
<p><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Useful skills:
</span></strong><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;font-weight:normal">Omics data, gene expression, multi model data<o:p></o:p></span></strong></p>
<p><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Description</span></strong><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;font-weight:normal">:
</span></strong><span style="font-size:12.0pt">One of the major hallmarks of Alzheimer's Disease (AD) are protein aggregates (amyloid plaques) that accumulate in the brain. Last year UK DRI published a gene expression atlas (of ~20k genes) showing many processes
(such as inflammation and myelination) that are spatially affected by the presence of plaques (see
<a href="https://eur03.safelinks.protection.outlook.com/?url=http%3A%2F%2Falzmap.org%2F&data=04%7C01%7CTuring-Southampton%40ecs.soton.ac.uk%7C49e717b1367947ef2c0a08d92a80ba5b%7C4a5378f929f44d3ebe89669d03ada9d8%7C0%7C0%7C637587554624958274%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=J95w3JZoXnx5WnCMRWM%2BBF1sB%2FUtTo33b6iKLbeZtNY%3D&reserved=0" originalsrc="http://alzmap.org/" shash="T9tDu9RPZ/JPHAjQvCEwgUL9YeuMuVtgDVBb1hSmBmqrTOsgquJKJL2/mwJkVUMqkaAASNL08oUDg8QLy+WbZDwLMPxQBadc6/axESxJmkDN3OUvuQTfYE/oqgdwSpNgVdSf8pV8p30k16AsGhctuUKGEeURgdIHJfG7kYgahjk=">
alzmap.org</a>). </span><o:p></o:p></p>
<p><span style="font-size:12.0pt">Using <span style="color:black">spatial transcriptomics and microscopy imaging data,</span> this project will investigate the relation between plaque morphology and the gene expression data.
<span class="highwire-cite-metadata-doi">By better understanding what drives amyloid plaque morphology and distribution in an Alzheimer's brain UK DRI hope to better understand the role of plaques during the onset of AD, and ultimately find ways to treat this
disease.</span><o:p></o:p></span></p>
<p><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Challenge:
</span></strong><b><span style="font-size:12.0pt">Predicting where DNA binds proteins from sequence data: can computational models pay attention to distant genetic variants which experiments show affect binding?</span><strong><span style="font-family:"Calibri",sans-serif"><o:p></o:p></span></strong></b></p>
<p><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Essential:
</span></strong><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;font-weight:normal">Machine learning, predictive modelling, casual inference, feature selection</span></strong><o:p></o:p></p>
<p class="MsoNormal"><strong><span style="font-size:12.0pt;font-family:"Calibri",sans-serif">Useful:
</span></strong><span style="font-size:12.0pt;mso-fareast-language:EN-GB">Understanding of gene regulation and expression, omics data, neural networks and multimodal data<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt;mso-fareast-language:EN-GB">Description:
</span></b><span style="font-size:12.0pt">Existing deep learning models are able to predict where a DNA sequence is likely to bind to regulatory proteins. From these models we can get predictions about which DNA bases are most important for regulating binding.
These models have been trained on data from single individuals though: the training/validation data sets comprise different regions of the DNA sequence, rather than comparing the same genomic regions across individuals. This project will consider experimental
data (specificity histone QTLs) on how genetic variants within DNA sequences affect binding: it will evaluate whether computational models can pay attention to the right genetic variants, and whether this depends on their distance from the binding site. Using
the models which are evaluated as best recapitulating experimental data, we will aim to obtain predictions for the effects of Alzheimers-associated genetic variants on cell-type specific histone modifications.</span><b><span style="font-size:12.0pt;mso-fareast-language:EN-GB"><o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt">All queries and applications should be sent to
<a href="mailto:datastudygroup@turing.ac.uk">datastudygroup@turing.ac.uk</a>. The deadline for applications is June 14<sup>th
</sup>2021. <o:p></o:p></span></p>
</div>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">__________________________________<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt;mso-fareast-language:EN-GB">Susan Davies<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">Coordination Manager,
<a href="https://www.southampton.ac.uk/wsi/index.page?">Web Science Institute</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">University Liaison Manager,
<a href="https://www.southampton.ac.uk/wsi/alan-turing-institute/alan-turing-institute.page">
The Alan Turing Institute</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">Room 3041, Building 32<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">Web Science Institute<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">University of Southampton<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">Southampton SO17 1BJ<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB">M 07768 266464<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;mso-fareast-language:EN-GB"><a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwebsci21.webscience.org%2F&data=04%7C01%7CTuring-Southampton%40ecs.soton.ac.uk%7C49e717b1367947ef2c0a08d92a80ba5b%7C4a5378f929f44d3ebe89669d03ada9d8%7C0%7C0%7C637587554624968232%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=1qcO45xA5R6abmPNwiq4xRvw1owDKAguK7RQYf5Oj0o%3D&reserved=0" originalsrc="https://websci21.webscience.org/" shash="SSiqm/gYSwIYe0XfeCMeLnVgJ65dX7UqA7754u4Qd3wcB6/r9n6Q3lh+OCbt3uKcspkDXRfvMZcWt0PEzbHfWl2fOYhVAiNIGOCvYoJEgXbJkDPnd95F3/sOJUHYHRv0hyZbcYDe6MGaFH91silnXKC1PH+qUwgtldDgCyt4C/U=">websci21.webscience.org/</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><img border="0" width="480" height="64" style="width:5.0in;height:.6666in" id="Picture_x0020_1" src="cid:image002.jpg@01D75C71.F7841F90"></span><span style="mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
</div>
</body>
</html>