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<span style="margin: 0px; font-size: 12pt; color: black; background-color: white;"><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;">Dear all,</span></span>
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<span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;">Hope everyone is enjoying the nice spring weather!</span></div>
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<span style="font-size: 12pt; font-family: Calibri, Helvetica, sans-serif;">At this week's S3RI seminar</span><span style="font-size: 12pt; font-family: Calibri, Helvetica, sans-serif;"> (Thursday 11 March </span><span style="font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; background-color: white;">at
2 pm)</span><span style="font-size: 12pt; font-family: Calibri, Helvetica, sans-serif;"> John Aldrich (Economic, Social and Political Sciences, University of Southampton) is giving a talk on</span><br>
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<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; color: black;">"</span><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; color: black;"><span style="box-sizing: border-box; font-family: "Segoe UI", system-ui, "Apple Color Emoji", "Segoe UI Emoji", sans-serif; font-size: 12pt;">Fisher’s
Eugenics and Fisher’s Statistics</span></span><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; color: black;">"</span><span style="margin: 0px; font-size: 12pt; font-family: "Times New Roman", serif; color: black;"></span></p>
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<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; color: black;"> </span><span style="margin: 0px; font-size: 12pt; font-family: "Times New Roman", serif; color: black;"></span></p>
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<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; background-color: white; color: black;">Please see below for the details of the talk and how to
join the seminar online.</span><span style="margin: 0px; font-size: 12pt; font-family: "Times New Roman", serif; color: black;"></span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; background-color: white; color: black;"> </span><span style="margin: 0px; font-size: 12pt; font-family: "Times New Roman", serif; color: black;"></span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; background-color: white; color: black;">Have a great week and hope to see you at the seminar on
Thursday!</span><span style="margin: 0px; font-size: 12pt; font-family: "Times New Roman", serif; color: black;"></span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; background-color: white; color: black;"> </span><span style="margin: 0px; font-size: 12pt; font-family: "Times New Roman", serif; color: black;"></span></p>
<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; background-color: white; color: black;">Kind regards,</span><span style="margin: 0px; font-size: 12pt; font-family: "Times New Roman", serif; color: black;"></span></p>
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</span><span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; background-color: white; color: black;">Jessie</span></p>
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<div style="margin: 0px; background-color: white; color: black;"><span style="margin: 0px; font-family: Arial, Helvetica, sans-serif; color: rgb(32, 31, 30); background-color: white;"><span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; background-color: white;">
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<p style="background-color: white; margin-top: 0px; margin-bottom: 0px;"><span style="margin:0px;font-size:12pt;font-family:Calibri, Helvetica, sans-serif"><br>
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<span style="margin: 0px; font-size: 15px; font-family: Calibri, Arial, Helvetica, sans-serif; background-color: white; color: black;"><span style="margin:0px;font-size:12pt;font-family:Calibri, Helvetica, sans-serif"><b><em><strong><span style="color: rgb(0, 0, 0); font-family: "Segoe UI", system-ui, "Apple Color Emoji", "Segoe UI Emoji", sans-serif; font-size: 12pt; background-color: rgb(255, 255, 255); display: inline !important;">Fisher’s
Eugenics and Fisher’s Statistics</span></strong></em></b></span></span></span></p>
<div style="margin: 0px; background-color: white; color: black;"><span style="margin:0px;font-size:12pt"><i></i></span><span style="margin:0px;font-size:12pt;font-family:Calibri, Helvetica, sans-serif"><span style="color: rgb(0, 0, 0); background-color: rgb(255, 255, 255); display: inline !important; font-size: 12pt;">John
Aldrich (</span><span style="color: rgb(0, 0, 0); background-color: rgb(255, 255, 255); display: inline !important;"><span style="color: rgb(0, 0, 0); background-color: rgb(255, 255, 255); display: inline !important; font-size: 12pt;">Economic, Social and
Political Sciences, University of Southampton)</span><span style="color: rgb(0, 0, 0); background-color: rgb(255, 255, 255); display: inline !important;"><span style="font-size: 12pt;"> </span></span></span></span><i><span style="margin: 0px; font-size: 12pt; background-color: white;"></span></i></div>
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</span></span></span></span></div>
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<span style="box-sizing: border-box; font-family: "Segoe UI", system-ui, "Apple Color Emoji", "Segoe UI Emoji", sans-serif; font-size: 12pt;">In 1911 a Cambridge mathematics undergraduate Ronald Fisher (1890-1962) revealed himself as a eugenist with an interest
in the underlying sciences of genetics and statistics. Fisher had brilliant careers in those sciences but he was a life-long supporter of eugenics and for a decade occupied a chair of eugenics. This paper considers how this engagement with eugenics influenced
his statistical work. My conclusion is that it was less than might be expected.</span><span style="margin:0px;font-size:12pt;font-family:Calibri, Helvetica, sans-serif"></span>
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<span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; color: black; font-size: 12pt;"><To Join the Online Seminar><br>
</span><span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;"><b>Join on your computer or mobile app</b></span>
<div style="margin:0px 0px 20px">
<div style="margin-bottom:20px"><a data-cke-saved-href="https://teams.microsoft.com/l/meetup-join/19%3a71f0ed99e3ce45219eef73b9cbd1b0f3%40thread.tacv2/1614874424778?context=%7b%22Tid%22%3a%224a5378f9-29f4-4d3e-be89-669d03ada9d8%22%2c%22Oid%22%3a%22e8a58481-ba8c-4921-b869-4a905d652ae7%22%7d" href="https://teams.microsoft.com/l/meetup-join/19%3a71f0ed99e3ce45219eef73b9cbd1b0f3%40thread.tacv2/1614874424778?context=%7b%22Tid%22%3a%224a5378f9-29f4-4d3e-be89-669d03ada9d8%22%2c%22Oid%22%3a%22e8a58481-ba8c-4921-b869-4a905d652ae7%22%7d" target="_blank" rel="noreferrer noopener" style="font-size: 14px; font-family: "Segoe UI Semibold", "Segoe UI", "Helvetica Neue", Helvetica, Arial, sans-serif; text-decoration: underline; color: rgb(98, 100, 167);" class="me-email-headline"><span style="font-size: 12pt;">Click
here to join the meeting</span></a></div>
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<div style="margin-bottom:4px"><span style="font-size: 12pt; color: rgb(37, 36, 36); font-weight: bold;">Or call in (audio only)</span></div>
<div style="margin-bottom:4px"><a data-cke-saved-href="tel:+442037940272,,746795409# " href="tel:+442037940272,,746795409# " style="font-size: 14px; text-decoration: underline; color: rgb(98, 100, 167);"><span style="font-size: 12pt;">+44 20 3794 0272,,746795409#</span></a><span style="font-size: 12pt;">
</span><span style="font-size: 12pt; color: rgb(37, 36, 36);"> United Kingdom, London
</span></div>
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<span style="font-size: 12pt; color: rgb(37, 36, 36);">Phone Conference ID: </span>
<span style="color: rgb(37, 36, 36); font-size: 12pt;">746 795 409#</span></div>
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<span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; background-color: white; letter-spacing: 0.15pt; color: black; font-size: 12pt;"><Details for jointing S3RI team on Microsoft Teams></span></p>
<p style="font-family: "Times New Roman", serif; background-color: white; margin: 0px; color: black;">
<span style="margin: 0px; font-family: Calibri, Helvetica, sans-serif; background-color: white; letter-spacing: 0.15pt; color: black; font-size: 12pt;">If you would like to join the S3RI team on Microsoft Teams, please use the link below:</span><span style="margin: 0px; font-size: 10.5pt; font-family: Arial, sans-serif; color: rgb(60, 64, 67); background-color: white; letter-spacing: 0.15pt;"><br>
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<span style="margin: 0px; font-size: 12pt; font-family: Calibri, Helvetica, sans-serif; color: black;"><a href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.google.com%2Furl%3Fq%3Dhttps%3A%2F%2Fteams.microsoft.com%2Fl%2Fteam%2F19%25253a71f0ed99e3ce45219eef73b9cbd1b0f3%252540thread.tacv2%2Fconversations%3FgroupId%253D260706f2-7819-4bfe-920a-3d55825d8e9c%2526tenantId%253D4a5378f9-29f4-4d3e-be89-669d03ada9d8%26sa%3DD%26source%3Dcalendar%26usd%3D2%26usg%3DAOvVaw2XvLgdTxMOK_D8EYzydQd6&data=04%7C01%7CTuring-Southampton%40ecs.soton.ac.uk%7C01baf70c86f04fac854a08d8e24436e6%7C4a5378f929f44d3ebe89669d03ada9d8%7C0%7C0%7C637508129962528196%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=FuL%2FjxsodCTNCejnrIBkmo9hQGMpC9xM7CNUOI%2BMYuY%3D&reserved=0" originalsrc="https://www.google.com/url?q=https://teams.microsoft.com/l/team/19%253a71f0ed99e3ce45219eef73b9cbd1b0f3%2540thread.tacv2/conversations?groupId%3D260706f2-7819-4bfe-920a-3d55825d8e9c%26tenantId%3D4a5378f9-29f4-4d3e-be89-669d03ada9d8&sa=D&source=calendar&usd=2&usg=AOvVaw2XvLgdTxMOK_D8EYzydQd6" shash="Y+fX8FnYoRpIpGycqkkeHH7tbHdHvudLILnTiIfFGCsNCTEcoNH+L9poIu8fmtZi7n9o8jI0KBTx5EwG55cNhH0e135hntpXl2x2lGtjkEyJCYiT5653DMyW8UO2VPTTmPoC6sOsC3jX2kmO9CKE1TWlmnsb0sXYstf6Gol08ho=" target="_blank" rel="noopener noreferrer" data-auth="VerificationFailed" originalsrc="https://www.google.com/url?q=https://teams.microsoft.com/l/team/19%253a71f0ed99e3ce45219eef73b9cbd1b0f3%2540thread.tacv2/conversations?groupId%3D260706f2-7819-4bfe-920a-3d55825d8e9c%26tenantId%3D4a5378f9-29f4-4d3e-be89-669d03ada9d8&sa=D&source=calendar&usd=2&usg=AOvVaw2XvLgdTxMOK_D8EYzydQd6" shash="NGA7ggaomgyt5vmR/ERRKyTIU8a2Ihws/dXaa+5VWyFjVCj3ngUBvCeEGq4l7a9yBnhxE/quwfw/3/0dqE/JzhHZGZuMwIdVQ4dhVvrvTlaKnCiDgDNQasGd/Rlu8nO4MQ1ZW3VIAhVEHTpFb0yUwRcQPTbzA1D06d4UWtVuY9Q=" title="" style="margin:0px"><span style="font-size: 12pt;">https://teams.microsoft.com/l/team/19%3a71f0ed99e3ce45219eef73b9cbd1b0f3%40thread.tacv2/conversations?groupId=260706f2-7819-4bfe-920a-3d55825d8e9c&tenantId=4a5378f9-29f4-4d3e-be89-669d03ada9d8</span></a></span></span></p>
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> Chieh-Hsi Wu <C-H.Wu@soton.ac.uk><br>
<b>Sent:</b> 25 February 2021 09:56<br>
<b>To:</b> S3ri-all@lists.soton.ac.uk <S3ri-all@lists.soton.ac.uk>; Socsci-staff-academic@lists.soton.ac.uk <Socsci-staff-academic@lists.soton.ac.uk>; socsci-phd-all@lists.soton.ac.uk <socsci-phd-all@lists.soton.ac.uk>; maths-stats-lists.soton.ac.uk-aliases
<maths-stats@lists.soton.ac.uk>; Rong Peng <rp2e13@soton.ac.uk>; Socsci-ec-all@lists.soton.ac.uk <Socsci-ec-all@lists.soton.ac.uk>; James Hall <J.E.Hall@soton.ac.uk>; maths-stats-pgr@all.soton.ac.uk <maths-stats-pgr@all.soton.ac.uk>; Orouba Almilaji <oalmilaji@bournemouth.ac.uk>;
David Culliford <D.J.Culliford@soton.ac.uk>; Christel de Bruijn <Christel.DeBruijn@bcu.ac.uk>; Turing-Southampton@ecs.soton.ac.uk <Turing-Southampton@ecs.soton.ac.uk>; Leo Westbury <lw@mrc.soton.ac.uk>; Faridah Alruwaili <F.Alruwaili@soton.ac.uk>; Peter Thomas
<PThomas@bournemouth.ac.uk>; Giuseppe Di Nardo <giuseppe.dinardo@hotmail.it>; Aditya Sivanand <A.Sivanand@soton.ac.uk>; Adetola Adediran <A.A.Adediran@soton.ac.uk><br>
<b>Subject:</b> Re: S3RI seminar: Geert Verbeke (KU Leuven, Hasselt University), Thursday 25 February</font>
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<span style="font-size:12pt; font-family:Calibri,Helvetica,sans-serif">Dear all,</span></div>
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<span style="font-size:12pt; font-family:Calibri,Helvetica,sans-serif">Hope everyone is having a good week.</span></div>
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<span style="font-size:12pt; font-family:Calibri,Helvetica,sans-serif">Just a reminder that, a</span><span style="font-size:12pt; font-family:Calibri,Helvetica,sans-serif">t today's S3RI seminar</span><span style="font-size:12pt; font-family:Calibri,Helvetica,sans-serif"> </span><span style="font-size:12pt; background-color:white; font-family:Calibri,Helvetica,sans-serif">at
2 pm</span><span style="font-size:12pt; font-family:Calibri,Helvetica,sans-serif">, Prof Geert Verbeke (KU Leuven, Hasselt University) is speaking to us about</span>
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<p style="background-color:white; margin-top:0px; margin-bottom:0px"><span style="margin:0px; font-size:12pt; color:black; font-family:Calibri,Helvetica,sans-serif">"How to correct for baseline covariates in longitudinal clinical trials?"</span><span style="margin:0px; font-size:12pt; font-family:"Times New Roman",serif; color:black"></span></p>
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<p style="background-color:white; margin-top:0px; margin-bottom:0px"><span style="margin:0px; font-size:12pt; color:black; font-family:Calibri,Helvetica,sans-serif"> </span><span style="margin:0px; font-size:12pt; font-family:"Times New Roman",serif; color:black"></span></p>
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<p style="background-color:white; margin-top:0px; margin-bottom:0px"><span style="margin:0px; font-size:12pt; color:black; background-color:white; font-family:Calibri,Helvetica,sans-serif">Please see below for the details of the talk and how to join the seminar
online.</span><span style="margin:0px; font-size:12pt; font-family:"Times New Roman",serif; color:black"></span></p>
<p style="background-color:white; margin-top:0px; margin-bottom:0px"><span style="margin:0px; font-size:12pt; color:black; background-color:white; font-family:Calibri,Helvetica,sans-serif"> </span><span style="margin:0px; font-size:12pt; font-family:"Times New Roman",serif; color:black"></span></p>
<p style="background-color:white; margin-top:0px; margin-bottom:0px"><span style="margin:0px; font-size:12pt; color:black; background-color:white; font-family:Calibri,Helvetica,sans-serif">Hope to see you at the seminar today (at 2 pm)!</span><span style="margin:0px; font-size:12pt; font-family:"Times New Roman",serif; color:black"></span></p>
<p style="background-color:white; margin-top:0px; margin-bottom:0px"><span style="margin:0px; font-size:12pt; color:black; background-color:white; font-family:Calibri,Helvetica,sans-serif"> </span><span style="margin:0px; font-size:12pt; font-family:"Times New Roman",serif; color:black"></span></p>
<p style="background-color:white; margin-top:0px; margin-bottom:0px"><span style="margin:0px; font-size:12pt; color:black; background-color:white; font-family:Calibri,Helvetica,sans-serif">Kind regards,</span><span style="margin:0px; font-size:12pt; font-family:"Times New Roman",serif; color:black"></span></p>
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</span><span style="margin:0px; font-size:12pt; color:black; background-color:white; font-family:Calibri,Helvetica,sans-serif">Jessie</span></p>
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<span style="margin:0px; font-size:15px; font-family:Calibri,Arial,Helvetica,sans-serif; color:rgb(0,0,0); background-color:rgb(255,255,255)"><span style="margin:0px; font-size:12pt; font-family:Calibri,Helvetica,sans-serif"><b><em><strong>How to correct for
baseline covariates in longitudinal clinical trials?</strong></em></b></span></span></span></p>
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<span style="margin:0px; font-size:12pt"><i></i></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Geert Verbeke (KU Leuven, Hasselt University)</span><i><span style="margin:0px; font-size:12pt; background-color:rgb(255,255,255); display:inline!important"></span></i></div>
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<span style="margin:0px; font-size:12pt; font-family:Calibri,Arial,Helvetica,sans-serif; color:rgb(0,0,0); background-color:rgb(255,255,255)"></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">In clinical trials, mixed models are
becoming more popular for the analysis of longitudinal data. The main motivation is often expected dropout which can easily be handled through the analysis of the longitudinal trajectories. In many situations, analyses are corrected for baseline covariates
such as study site or stratification variables. Key questions are then how to perform a longitudinal analysis correcting for baseline covariates, and how sensitive are the results with respect to choices made and models used?</span>
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<span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">In this presentation, we will first present and compare a number of techniques available to correct for baseline covariates within the context of the linear mixed model for continuous outcomes.
Second, we will study the sensitivity of the various techniques in case the baseline correction is based on a wrong model or does not include important covariates. Finally, our findings will be used to formulate some general guidelines relevant in a clinical
trial context. All findings and results will be illustrated extensively using data from a real clinical trial.</span>
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