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<span style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;">Dear all,</span><br>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Hope everyone has been having a good week.</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">At today's S3RI seminar at 2 pm, we have Dr Julia Brettschneider speaking to us about</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">"Non-parametric methods for point pattern analysis in microscopic images of protein abundance and other applications."</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Please see below for the details of the talk and how to join the seminar online. This seminar will be recorded.</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Hope to see you at the seminar (at 2 pm)!</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Kind regards,</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Jessie</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt"><b><i>Non-parametric methods for point pattern analysis in microscopic images of protein abundance and other applications
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">Julia Brettschneider (University of Warwick)</span></div>
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<div><span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">We have developed statistics and a testing procedure free of distributional assumptions to quantify the significance of calculated differences between point pattern structures as observed,
for example, in fluorescent microscopic images of protein abundance. Sensitivity is investigated in a simulation study of unmarked and marked point patterns. We illustrate our methods in experimental data shedding light on the interplay between subcellular
structures called microtubules and chemicals involved in mitosis.</span></div>
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<span style="font-family:Calibri,Helvetica,sans-serif; font-size:12pt">We further look at the temporal evolution of such spatial abundance distribution. We suggest a methodology that both estimates local bulk movement patterns and compares two such patterns
in a test of dependence. Application to both simulated and real data sets from microscopy indicate that our methodology may be effectively applied to the problem of colocalisation, which is of interest for understanding the interaction between different biomolecular
species or point patterns in other examples.</span><br>
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