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<p>Dear all,</p>
<p>On Thursday (23 May) at 2pm in <span class="event-where">*58 / 1065*, we have an S3RI seminar from Fang Wan (Lancaster University) on
</span><span class="event-where"><span class="event-description">"</span></span><span class="event-where"><span class="event-description"><span class="event-description"><span class="event-details-label"></span><span class="event-description">Subgroup analysis
of treatment effects for misclassified biomarkers with time-to-event data</span></span>". Details are given below.<br>
</span></span></p>
<p><span class="event-where"><span class="event-description"><span><span class="event-description">The talk will be followed by tea and cake in the staff reading room on level 4 of building 54.
</span></span></span></span><span class="event-where"><span class="event-description"><span><span class="event-description">All are welcome!</span></span></span></span></p>
<p><span class="event-where"><span class="event-description"><span><span class="event-description">This will be the last S3RI seminar of this academic year. Thanks to everyone who has suggested speakers, chaired seminars, entertained speakers, made hotel and
taxi bookings, or helped out with the refreshments! If you have suggestions for speakers for next year, please let me know.<br>
</span></span></span></span></p>
<p><span class="event-where"><span class="event-description"><span>Best wishes,</span></span></span></p>
<p><span class="event-where"><span class="event-description"><span>Helen</span></span></span></p>
<p><span class="event-where"><span class="event-description"><span><br>
</span></span></span></p>
<p><span class="event-details-label"></span><span class="event-description">Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data
<br>
</span></p>
<p><span class="event-description">Fang Wan, Lancaster University <br>
</span></p>
<p><span class="event-description">Analysing subgroups defined by biomarkers is of increasing importance in clinical research. In many situations the biomarker is subject to misclassificati<wbr>on error, meaning the subgroups are identified with imperfect sensitivity
and specificity. In these cases, it is improper to assume the Cox proportional hazards model for the subgroup specific treatment effects for time-to-event data with respect to the true subgroups, since the survival distributions with respect to the diagnosed
subgroups will not adhere to the proportional hazards assumption. This precludes the possibility of using simple adjustment procedures. Two approaches to modelling are considered; the corrected score approach of Zucker and Spiegelman (2008) and a method based
on formally modelling the data as a mixture of Cox models using an EM algorithm for estimation. An estimate of the overall population treatment effect is also provided.</span></p>
<br>
<span class="event-where"><span class="event-description"><span><span class="event-description"><span><span class="event-description"></span><span class="event-description"><span class="event-description">For the current schedule of S3RI seminars, see
<a class="moz-txt-link-freetext" href="https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftinyurl.com%2Fs3riseminar&data=01%7C01%7C%7Ccfa03c2753a84f054f4908d6ddaa971f%7C4a5378f929f44d3ebe89669d03ada9d8%7C0&sdata=PT58rpKC%2FUIiIeX%2BOvi0504oL%2BPZZfwBiFEsHc7YGU0%3D&reserved=0" originalsrc="https://tinyurl.com/s3riseminar" shash="k+3yTlCq17ATAUuYC2cOOjSJBAMa44kxBzm4VIi8Ve5V5sUYjLn3vKIisdO+qO3DG2Ck1R3j8vbJZbKxUhciYC6M6WHYzFIW/fSM7N+tHMJmw+OiCJrEPaMi4TannJUh6XuQBUaBxrH1/dId3Jibbnqu61FOtXPMBqQzS5RvkXg=">
https://tinyurl.com/s3riseminar</a> </span></span></span></span></span></span></span><br>
<p><span class="event-where"><span class="event-description"><span><span class="event-description"></span></span></span></span></p>
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