[Turing-Southampton] S3RI seminar: Julia Brettschneider (University of Warwick), Thursday 4 March

[Chieh-Hsi Wu]

Dear all,

Hope everyone has been having a good week.

At today's S3RI seminar at 2 pm, we have Dr Julia Brettschneider speaking to us about

"Non-parametric methods for point pattern analysis in microscopic images of protein abundance and other applications."

Please see below for the details of the talk and how to join the seminar online. This seminar will be recorded.

Hope to see you at the seminar (at 2 pm)!

Kind regards,

Jessie



Non-parametric methods for point pattern analysis in microscopic images of protein abundance and other applications
Julia Brettschneider (University of Warwick)

We have developed statistics and a testing procedure free of distributional assumptions to quantify the significance of calculated differences between point pattern structures as observed, for example, in fluorescent microscopic images of protein abundance. Sensitivity is investigated in a simulation study of unmarked and marked point patterns. We illustrate our methods in experimental data shedding light on the interplay between subcellular structures called microtubules and chemicals involved in mitosis.

We further look at the temporal evolution of such spatial abundance distribution. We suggest a methodology that both estimates local bulk movement patterns and compares two such patterns in a test of dependence. Application to both simulated and real data sets from microscopy indicate that our methodology may be effectively applied to the problem of colocalisation, which is of interest for understanding the interaction between different biomolecular species or point patterns in other examples.


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