[Turing-Southampton] S3RI seminar: Geert Verbeke (KU Leuven, Hasselt University), Thursday 25 February

[Chieh-Hsi Wu]

Dear all,

Hope everyone is having a good week.

Just a reminder that, at today's S3RI seminar at 2 pm, Prof Geert Verbeke (KU Leuven, Hasselt University) is speaking to us about



"How to correct for baseline covariates in longitudinal clinical trials?"



Please see below for the details of the talk and how to join the seminar online.



Hope to see you at the seminar today (at 2 pm)!



Kind regards,

Jessie


How to correct for baseline covariates in longitudinal clinical trials?

Geert Verbeke (KU Leuven, Hasselt University)

In clinical trials, mixed models are becoming more popular for the analysis of longitudinal data. The main motivation is often expected dropout which can easily be handled through the analysis of the longitudinal trajectories. In many situations, analyses are corrected for baseline covariates such as study site or stratification variables. Key questions are then how to perform a longitudinal analysis correcting for baseline covariates, and how sensitive are the results with respect to choices made and models used?

In this presentation, we will first present and compare a number of techniques available to correct for baseline covariates within the context of the linear mixed model for continuous outcomes. Second, we will study the sensitivity of the various techniques in case the baseline correction is based on a wrong model or does not include important covariates. Finally, our findings will be used to formulate some general guidelines relevant in a clinical trial context. All findings and results will be illustrated extensively using data from a real clinical trial.


<To Join the Online Seminar>
Join on your computer or mobile app
Click here to join the meeting<https://teams.microsoft.com/l/meetup-join/19%3a71f0ed99e3ce45219eef73b9cbd1b0f3%40thread.tacv2/1613475816330?context=%7b%22Tid%22%3a%224a5378f9-29f4-4d3e-be89-669d03ada9d8%22%2c%22Oid%22%3a%22e8a58481-ba8c-4921-b869-4a905d652ae7%22%7d>
Or call in (audio only)
+44 20 3794 0272,,164475059#<tel:+442037940272,,164475059#>   United Kingdom, London
Phone Conference ID: 164 475 059#



<Details for jointing S3RI team on Microsoft Teams>

If you would like to join the S3RI team on Microsoft Teams, please use the link below:

https://teams.microsoft.com/l/team/19%3a71f0ed99e3ce45219eef73b9cbd1b0f3%40thread.tacv2/conversations?groupId=260706f2-7819-4bfe-920a-3d55825d8e9c&tenantId=4a5378f9-29f4-4d3e-be89-669d03ada9d8<https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.google.com%2Furl%3Fq%3Dhttps%3A%2F%2Fteams.microsoft.com%2Fl%2Fteam%2F19%25253a71f0ed99e3ce45219eef73b9cbd1b0f3%252540thread.tacv2%2Fconversations%3FgroupId%253D260706f2-7819-4bfe-920a-3d55825d8e9c%2526tenantId%253D4a5378f9-29f4-4d3e-be89-669d03ada9d8%26sa%3DD%26source%3Dcalendar%26usd%3D2%26usg%3DAOvVaw2XvLgdTxMOK_D8EYzydQd6&data=04%7C01%7CTuring-Southampton%40ecs.soton.ac.uk%7C639a29620d084536341b08d8d973a34a%7C4a5378f929f44d3ebe89669d03ada9d8%7C0%7C0%7C637498437963194375%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=RfGNBwk967e2kUogCoMHc%2FDg3XJTisut%2BlhGKUN%2Fu8o%3D&reserved=0>


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