[Turing-Southampton] S3RI seminar: Fang Wan, Thursday 2-3pm

[Ogden H.E.]

Dear all,

On Thursday (23 May) at 2pm in *58 / 1065*, we have an S3RI seminar from Fang Wan (Lancaster University) on "Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data". Details are given below.

The talk will be followed by tea and cake in the staff reading room on level 4 of building 54. All are welcome!

This will be the last S3RI seminar of this academic year. Thanks to everyone who has suggested speakers, chaired seminars, entertained speakers, made hotel and taxi bookings, or helped out with the refreshments! If you have suggestions for speakers for next year, please let me know.

Best wishes,

Helen


Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data

Fang Wan, Lancaster University

Analysing subgroups defined by biomarkers is of increasing importance in clinical research. In many situations the biomarker is subject to misclassification error, meaning the subgroups are identified with imperfect sensitivity and specificity. In these cases, it is improper to assume the Cox proportional hazards model for the subgroup specific treatment effects for time-to-event data with respect to the true subgroups, since the survival distributions with respect to the diagnosed subgroups will not adhere to the proportional hazards assumption. This precludes the possibility of using simple adjustment procedures. Two approaches to modelling are considered; the corrected score approach of Zucker and Spiegelman (2008) and a method based on formally modelling the data as a mixture of Cox models using an EM algorithm for estimation. An estimate of the overall population treatment effect is also provided.

For the current schedule of S3RI seminars, see https://tinyurl.com/s3riseminar<https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftinyurl.com%2Fs3riseminar&data=01%7C01%7C%7Ccfa03c2753a84f054f4908d6ddaa971f%7C4a5378f929f44d3ebe89669d03ada9d8%7C0&sdata=PT58rpKC%2FUIiIeX%2BOvi0504oL%2BPZZfwBiFEsHc7YGU0%3D&reserved=0>
-------------- next part --------------
An HTML attachment was scrubbed...
URL: http://mailman.ecs.soton.ac.uk/pipermail/turing-southampton/attachments/20190521/7294f4b9/attachment.html