[Turing-Southampton] S3RI seminar: Dirk Husmeier, Thursday 2-3pm

[Helen Ogden]

Dear all,

On Thursday (7 February) at 2pm in 54 / 7035 (7B), we have an S3RI 
seminar from Dirk Husmeier (University of Glasgow) on "Statistical 
inference in soft-tissue mechanics and haemodynamics with an application 
to prognostication of myocardial infarction and pulmonary hypertension". 
Details are given below.

The seminar will also be available via a live web-cast at
https://coursecast.soton.ac.uk/Panopto/Pages/Viewer.aspx?id=f77021fe-662c-427c-9c7a-a9ea0088932a

The talk will be followed by tea and cake in the staff reading room on 
level 4 of building 54.

All are welcome!

Best wishes,

Helen

Statistical inference in soft-tissue mechanics and haemodynamics with an 
application to prognostication of myocardial infarction and pulmonary 
hypertension

Dirk Husmeier, University of Glasgow

A central problem in biomechanical studies of personalised human left 
ventricular (LV) modelling is estimating the material properties from 
in-vivo clinical MRI measurements in a time frame suitable for use in 
the clinic. Understanding these properties can provide insight into 
heart function or dysfunction and help inform personalised treatment. 
However, finding a solution to the differential equations which describe 
the myocardium through numerical integration can be computationally 
expensive. To circumvent this issue, we use the concept of statistical 
emulation to infer the myocardium properties of a healthy volunteer in a 
viable clinical time frame using in-vivo MRI data. Emulation methods 
avoid computationally expensive simulations from the LV model by 
replacing it with a surrogate model inferred from simulations generated 
before the arrival of a patient, vastly improving efficiency at the 
clinic. I will compare and contrast various emulation strategies, 
discuss uncertainty quantification and (if time permits) discuss an 
extension of this framework to fluid dynamics in the pulmonary blood 
circulation system for prognostication of pulmonary hypertension.


For the current schedule of S3RI seminars, see 
https://tinyurl.com/s3riseminar

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