[Turing-Southampton] S3RI seminar: Andrew Titman, Thursday 2-3pm

[Helen Ogden]

Dear all,

On Thursday (22 November) at 2pm in 54 / 7035 (7B), we have an S3RI 
seminar from Andrew Titman (Lancaster University) on "Informative 
observation in multi-state models". Details are given below.

The seminar will also be available via a live web-cast at

https://coursecast.soton.ac.uk/Panopto/Pages/Viewer.aspx?id=58feb0fd-5471-4145-846e-a990010a25ec

The talk will be followed by tea and cake in the staff reading room on 
level 4 of building 54.

All are welcome!

Best wishes,

Helen

Informative observation in multi-state models

Andrew Titman, Lancaster University

Data on multi-state disease processes often arise through intermittent 
observation of disease status at clinic visit times. This leads to 
interval-censored or panel-observed data. Standard analyses for such 
data usually assume that the examination times are non-informative of 
the disease process, meaning they are ignorable. However if clinic 
visits are potentially self-initiated and the disease is symptomatic, 
there is a risk that attendances will arise because a patient's 
condition has deteriorated leading to a form of selection bias. The talk 
will give an overview of existing approaches for dealing with 
informative observation times and the challenges to be overcome. There 
are analogies and connections with methods for missing data, but the 
methodology is less developed and informative observation is more often 
an issue of excess, rather than missing, observations. Focus will be 
given to methods for diagnosing the presence of informative observation 
and joint modelling approaches involving simultaneous modelling of the 
disease and visit processes. The methods are illustrated on data from 
post-heart transplantation patients.


For the current schedule of S3RI seminars, see 
https://tinyurl.com/s3riseminar

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